Janus Dendrimers for Drug Delivery
Fabrication of bilayered vesicles for the delivery of therapeutic agents
Dendrimers - molecular carriers whose branched layered architectures display a high number of controlled terminal groups as well as cavities for physical entrapment.
Designing vesicles with features such as uniform size distribution, biocompatibility, and tailored transport properties, presents a challenge for the fields of nanotechnology and nanomedicine. Dendrimers have shown to be promising delivery vehicles in biomedical applications. As molecular carriers, their branched layered architectures display a high number of controlled terminal groups as well as cavities for physical entrapment. Only in recent years have dendrimers comprised of heterogeneous segments (Janus dendrimers) been designed for biomedical application.
The objective of this research is to design and synthesize a series of supramolecular amphiphilic Janus dendrimers comprised of biocompatible polymeric segments that can self-assemble into narrow size distributed nanoparticles. These dendrimers are designed to combat issues often faced in nanomedicine such as biocompatibility and tunable transport properties. Our work will cast a new light on the design of supramolecular systems for biomedical applications.