The Ohio State University

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Polymers for Drug Delivery

Designing vesicles with features such as uniform size distribution, biocompatibility, and tailored transport properties, presents a challenge for the fields of nanotechnology and nanomedicine. Linear-dendritic hybrids and dendrimers have shown to be promising delivery vehicles in biomedical applications. As molecular carriers, their branched layered architectures display a high number of controlled terminal groups as well as cavities for physical entrapment. Only in recent years have these polymer constructs been applied for biomedical application.

Here we use our skills to design and synthesize libraries of supramolecular amphiphilic Janus dendrimers and linear dendritic hybrids comprised of biocompatible polymeric segments that can self-assemble into narrow size distributed nanoparticles. These polymers are designed to combat issues often faced in nanomedicine such as biocompatibility and tunable transport properties. Our achievements in the area of study have casted a new light on the design of supramolecular systems for theranostic applications.
Key words: polymer self-assembly, copolymers, dendrimers, linear-dendritic block copolymers
Representative work publication: Crosslinking PCL-PAMAM Linear Dendritic Block Copolymers (LDBC) for Theranostic Nanomedicine